Role of fl-arrestins in the activation and targeting of MAP kinases
| PAG Title | Role of fl-arrestins in the activation and targeting of MAP kinases |
| PAG ID | WIG000267 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | The binding of -arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kinase activation complex using -arrestin as a scaffold, with subsequent activation of a -arrestin-bound pool of ERK1/2. The receptor-arrestinERK complexes are localized to endosomal vesicles, and their formation does not result in nuclear translocation of activated ERK1/2 or stimulation of cell proliferation. The function of -arrestin-bound ERK1/2 is presently unknown. Activation of ERK1/2 by -arrestin scaffolds may favor the phosphorylation of plasma membrane, cytosolic, or cytoskeletal ERK1/2 substrates, or it may lead to transcriptional activation through the ERK-dependent activation of other kinases. The model depicts -arrestin scaffolding of the ERK1/2 MAP kinase cascade, based upon data obtained with the protease-activated PAR2 and angiotensin AT1a receptors. A similar mechanism has been proposed for regulation of the JNK3 MAP kinase cascade by AT1a receptors. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 1,182 |
| Information Content | Rich |
| Other IDs | M668 |
| Base PAG ID | WIG000267 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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